Extracellular Vesicles – A New Frontier in Regenerative Medicine

Discover the newest generation of naturally bioactive products for regenerative therapies.

What are Extracellular Vesicles or EV’s?

-Involved in cell-to-cell communication
-Natural signals with no preservatives
-Approximately 30nm – 150nm in size

Extracellular Vesicles Contain:
More than 1,000 regulatory proteins

Anti-inflammatory cytokines
Angiogenic growth factors
Matrix regenerative signals
Tumor suppressor signals
Inhibitors of apoptosis

Messenger RNA (mRNA) – ON SWITCH

Translated by recipient cells into new proteins that can regulate inflammatory cells and new vessel formation


May inhibit mRNA of chronic inflammatory cytokines and matrix catabolic enzymes

Extracellular Vesicles Are Not Small Cells

They are isolated from human bone marrow mesenchymal stem/ stromal cells (MSCs) and contain growth factors and extracellular vesicles including exosomes.

-They contain paracrine signals that assist with local cell-to-cell communication.
-They provide a wide array of regulatory proteins to stimulate and modulate many processes within the normal healing cascade.
-They are purified using proprietary cGMP processing and are sterile filtered and tested per USP<71> sterility testing.


Why Bone Marrow MSCs?

Peer reviewed published studies clearly indicate that BM-MSCs have a much higher safety profile and yield higher quality extracellular vesicles that deliver a more favorable profile of signaling factors vs. perinatal derived MSCs
Bone marrow derived MSCs are a much more characterized cell source.
Over 63,000 peer reviewed papers have been published on bone marrow derived MSCs vs. up to 1,200 on perinatal derived MSCs.
Given the reported differences in safety, quality, and efficacy of extracellular vesicles products, it is important for physicians to thoroughly investigate the extracellular vesicles product being considered.

Scientists have found that when sufficient levels of exosomes can be isolated and protected from degradation, treatment with exosomes can reproduce similar biological activity without requiring the addition of MSCs.

These observations have since prompted the development of extracellular vesicles including exosomes as an entire category of novel therapeutics.

Extracellular vesicles provide a natural and comprehensive activation of the body’s healing processes by systematically activating the complex array of cell signals required to restore and maintain tissue health. This is the newest generation of naturally bioactive products for regenerative therapies.
Direct Biologics EVs contain paracrine signals that assist with local cell-to-cell communication. They induce changes in nearby cells that create the appropriate healing environment and aid in tissue repair.


How Many Extracellular Vesicles Treatments Will I Require?

On average, people may see effects and potential relief within 4 weeks of the initial treatment. Many people with pain, inflammation, degenerative diseases, or strains report significant improvements after a single treatment.

As every one of us is biochemically unique, response times and frequency vary.

PA Sheri Injecting Exosomes into Shoulder

Extracellular Vesicles Shoulder Injection

What Should I Expect With Extracellular Vesicles?



We will advise you about any specific protocols for your Extracellular Vesicles procedure in preparation for your appointment. Most patients resume normal daily function post-procedure, but it is recommended that strenuous exercise be avoided immediately after your procedure to allow the success of treatment. We will also go over and discuss the post-procedure and appropriate follow up.

Extracellular Vesicles are known to stimulate stem cell bioactivity and direct communication. In topical applications, they have been shown to help in repair and reconstruction of tissue.

pa sheri injecting exosomes into knee

Extracellular Vesicles Knee Injections

pa sheri injecting exosomes into knee

Extracellular Vesicles IV


XoFlo Facial Rejuvenation


XoFlo IV

XoFlo Overview Studies

XoFlo Overview Packet


Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

ExoFlo and Covid Clinical Study

Some of our current Extracellular Vesicles Procedures include:

Hairloss Rejuvenation

Extracellular Vesicles for Hair Loss Regeneration

Let’s signal your hair follicles to turn on and start regenerating and repairing.

Hair Rejuvenation

Facial Rejuvenation

XoFlo Facial - Facial Rejuvenation

Extracellular Vesicles for Facial Rejuvenation include injections and Microneedling into the skin.

XoFlo Facial Rejuvenation

Sexual Wellness

Extracellular Vesicles for Sexual Wellness

Extracellular vesicles are regarded as the purest form of cellular signaling available. Can be used for the O-Shot or P-Shot for the Xo-Shot!

Sexual Wellness

Contact Rejuvenate 528 Med Spa Today!


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PRP - Platelet Rich Plasma

PRP in Sarasota

PRP Treatments use your own blood derived growth factors to activate your own stem cells accelerating healing and rejuvenation.

PRP – Platelet Rich Plasma

Stem Cell Growth Factors & Cytokines

Stem Cell Growth Factors & Cytokines

Stem Cell Growth Factors & Cytokines from Mesenchymal Stem Cells for Regenerative Aesthetics

Stem Cells Growth Factors

All Services

All Services Rejuvenate 528

View a full list of all our services here. Please contact us with any questions and to set your appointment when ready.